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Thursday, 23 February 2012

MOA of some common drugs




1.Nalidixic Acid-Prevent DNA sysnthesis


2.Dapsone-Folic acid sysnthesis inhibitor


3.Vinca alkaloid-Mitotic Spindle formation prevention


4.anthracycline-Intercalation of DNA


5.Methotraxate- Folic acid reductase inhibitor.


6.Warfarin-Vit k antagonist


7.Zidovudine- Inhibits the enzyme reverse tranascriptase ,preventing DNA replication 


8.Metronidazole- disruption of helical structure of DNA


9.Tetracycline- Inhibits Protein smyntheses by acting on 30 S unit of ribosome


10.Erythromycin- Inhibits Protein smyntheses by acting on 50 S unit of ribosome


11.Chloroquine- Binds and alters properties of microbial and fungal DNA


12.Diazepam- GABA facilitator


13.Acetazolamide- Carbonic anhydrase inhibitor


14.Allopurinol- Xanthine oxidase inhibitor,inhibitor of uric acid


15.Fluconalzole- P450 enzyme 14α-demethylase Inhibitor


16.Salbutamol-Beta 2 receptor agonist


17.Tolnaftate- Inhibit squalene epoxidase which is necessray for ergosteral syns of fungal 
cell wall


18.Griesofulvin-inhibits fungal cell wall activity


19.Chloramphenicol-Inhibition of Protein syntheses


20.Levodopa- Replenish Brain deleted dopamine

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